Lepotitsa (cathedral)

Chapter: L2 · Cemetery & Cathedral
Where: 2-3 Cathedral: the main hall, once you place the Madonna of Grief and the Madonna of Sorrow on the blue pedestals. There are item boxes on the third level.

Weak point

The legs to make it kneel; then the head (the creature that pokes out of its head once it's hurt)

A bulbous mutation that sprays blue gas to turn civilians into zombies. At first it ignores you and hunts the civilians; once none are left, it comes for you. Shooting its body makes it vent grey gas, which knocks you down at close range (about 1.5 health blocks on Normal, per one source). The method every source agrees on: legs until it kneels, then a coup de grâce or a point-blank shotgun blast to the head. Kill it fast: saving the last two women (Jenny and Megan) earns I Prefer Them Alive.

Reward

The Underground Keycard by its corpse. Under the altar, a chest with 4,000 SP and 2 barrels behind the door. I Prefer Them Alive if Jenny and Megan survive: they stay by the altar, and one pew has a Green Herb + Red Herb.

Jenny and Megan always outrun it and only become vulnerable once they reach the altar. It dies faster on Amateur: if the achievement won't pop, lower the difficulty and buy damage skills (Firearm Lv3 + Lightning Hawk on a later run). No source gives its health in this fight.

Step by step

Before placing the second Madonna, reload everything and equip your strongest weapon: there are item boxes on the top level.
While it chases civilians, kill the freshly turned zombies from range: they drop Incendiary Grenades, which work very well on it. Use them freely.
When it comes for you, keep your distance and shoot the legs with the Semi-Auto Sniper Rifle (you've just picked it up) or the Wing Shooter. The shotgun up close is risky because of the gas.
A Remote Bomb or a hand grenade makes it kneel at once, and the coup de grâce finishes it.
Kneeling: coup de grâce or a shotgun blast to the head. Back off as it stands and repeat.
If it grabs you with its tongue (Tongue Shove), rotate the stick: failing puts you in Dying, and kills you if you were already in the red. Its gas on a Dying player kills them, so revive your partner right away.
In co-op, split the job: one player shoots the legs from range, the other waits closer with the shotgun or the knife to finish it the moment it kneels.