Mutated Dimitrescu

Chapter: 4 · Castle Dimitrescu
Where: The Tower of Worship battlements (the roof), then the top of the tower. It starts when you take the Dagger of Death's Flowers from the coffin.

Weak point

The human torso on the dragon's back (×2.0). The dragon body takes only ×1.2 (Knife ×0.8). Explosives do ×2.0 anywhere.

Three stretches. On the battlements, circle her and shoot the torso from behind; when she flies around the tower, knock her down with the F2 Rifle so she crashes and is left open. After "More blood", climb the stairs without fighting. At the top, in a tight space, shotgun the torso and dodge her charge.

Supplies: on the barrels at the top of the battlements' north-west stairs there are a First Aid Med ×1, Shotgun Ammo ×7 and Sniper Rifle Ammo ×15, plus a vase; at the top of the tower, 2 more vases with ammo.

Reward

Crystal Dimitrescu (25,000 Lei, automatic) and the That Sucked! challenge. Lady Killer (25,000 CP): beat her in under 2:30. Afterwards take the Dirty Flask from the crypt altar: the castle closes for good.

9,000 HP plus a separate 3,500 bar (probably the tower-top one, unconfirmed). Rough estimate at Standard's starting rank: an un-upgraded F2 Rifle shot takes about 600 off the torso (15 shots for the first bar) and a Pipe Bomb about 1,500. The handgun alone won't cut it: bring the M1897, the F2 Rifle and Pipe Bombs.

Village of Shadows: much faster and tougher. During the swarm, stand in the small watchtower on the side of the roof. Game8: magnum shots as she first appears on the stairs, the rifle while she flies, Mines and Pipe Bombs when she lands.
Lady Killer: easier on New Game+ with an upgraded F2 and shotgun.
Knives Out: get behind her and slash the back leg: she can't touch you there until she turns. Hide from the swarm and melee fast when she breaks the top of the tower.

Step by step

Take the battlement supplies before you spend any bullets.
Back away when she lunges, circle her and shoot the torso from behind with the handgun or shotgun. As she turns she does a damaging stomp: step away.
When she flies around the tower, shoot her body with the F2 Rifle. A good hit stuns her and she crashes onto the tower: unload the shotgun or a Pipe Bomb into the torso.
Insect swarm while she flies: get back into the doorway alcove you came out of. The insects can't reach you there.
When she says "More blood", you are moved to a stairwell higher up. Don't spend ammo: climb straight to the top.
Top of the tower: she flies around outside, then smashes in. Strafe to one side and shotgun the torso. When she faces you and turns red, stop firing and run to the other side: she is about to charge. Repeat until she falls.