Albert Wesker (Lost in Nightmares)

Chapter: LiN · Lost in Nightmares: The Spencer Estate
Where: The room at the end of the long corridor after you return to the mansion (after the cutscene with Spencer's body). Just before, at the top of the stairs: 2 M92F handguns and a First Aid Spray. Handgun ammo lies around the room.

Weak point

He can only be shot in a brief window mid-attack: he dodges bullets even from behind and at a distance. Melee counters after you dodge his dash.

He has his campaign abilities plus new QTE moves. The fight ends after a set time (3 minutes) or once you deal enough damage. You can just dodge it out, but driving him off early gives 3,000 points in Score Stars and the Kung Fu Fighting award.

The method: bait his dash with two handgun shots, dodge it and counter. About 3–4 counters are enough.

Reward

Kung Fu Fighting and 3,000 points in Score Stars if you drive him off before 3 minutes. If time runs out, no bonus.

The shots must be from long range; after dodging 3 he dashes at the shooter. Dodging that forced dash gives the normal prompt; dodging a dash he starts on his own gives the stronger tag-team prompt. Solo, your AI partner's shots break the pattern: one source advises not letting it pick up an M92F.

Trivia: dodging his punch-then-stomp shows "Flip Kick", but Jill does a cartwheel kick.

Step by step

From range, fire 2 handgun shots at him. He usually answers with a short cut-in and a dash.
Dodge with whatever prompt appears. On Amateur it's always the same one; on Professional you must hit the exact one. If the first strike lands, dodge the follow-up or you may die.
After a successful dodge, run in and press the melee prompt. If he went for your partner, you get a different prompt.
A full combo ends the fight at once: Chris, Left Hook → Right Hook → Body Blow → Heavy Blow → Finishing Combo; Jill, Reverse Kick → High Kick → Front Kick → Knee Strike → Double Heel Hop (Xbox: X, X, B, A, X+A; PlayStation: Square, Square, Circle, X, Square+X).
In co-op: when your partner dodges, don't shoot (it cancels the opening). If you both strike together, both hits count.
If he knocks you down, rotate the stick to recover. When he attacks your partner, you can save them.